Micromeritic Analysis of Pharmaceutical Powders: Particle Size Distribution of Paracetamol, Omeprazole, and Talc

Abstract

Micromeritics studies the particle size and distribution that affect the properties and quality of pharmaceutical preparations. This study aims to determine the particle size distribution of paracetamol, omeprazole, and talc using a sieving method. The study was conducted using a sieving method using 26, 40, and 60 mesh sieves for 5 minutes, then the percentage of retained particles and the average particle diameter (Dav) were calculated. The results showed that paracetamol was dominated by fine particles (96.86%). Omeprazole had a larger particle size with many retained on 40 and 60 mesh. Talc showed a wider particle distribution. The Dav values were 0.0221; 0.03135; and 0.03091, respectively. Thus, it can be concluded that the sieving method is effective in determining particle size distribution. Differences in particle size can affect the dissolution rate, flow properties, compressibility, and performance of drug formulations.